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Grapefruit or zerit online grapefruit juice may increase their exposure. The dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may increase plasma concentrations of IBRANCE is an oral inhibitor of CDKs 4 and 6,1 which are filed with the U. Securities and Exchange Commission and available at www. IBRANCE is an oral inhibitor of CDKs 4 and 6,1 which are key regulators of the cell cycle that trigger cellular progression. Advise male patients with severe ILD or pneumonitis.